Treat with care
نویسندگان
چکیده
منابع مشابه
Thalidomide. Treat with caution!
In 1953, thalidomide was synthesised and designed into a drug by researchers at Chemie Grunenthal in West Germany. It was a novel therapeutic agent that failed to control epileptic fits as anticipated from animal studies. However, it caused such drowsiness that it was subsequently marketed as a sedative. Its promotion ironically emphasised its safety as overdoses in animal tests failed to cause...
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The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids, novel agents, conventional cytotoxic agents, and high-dose chemotherapy with...
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3104. 60. Larson RA, Dodge RK, Burns CP, et al. A five-drug remission induction regimen with intensiveconsolidation for adults with acute lymphoblasticleukemia: cancer and leukemia group B study8811. Blood. 1995;85(8):2025-2037. 61. van Schie RM, Brüggemann RJ, HoogerbruggePM, te Loo DM. Effect of azole antifungal therapyon vincristine toxicity in childhood acutelymp...
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Critical issues in determining therapeutic strategies for patients with myelodysplastic syndromes (MDSs), who usually die of bone marrow failure with or without conversion to acute myeloid leukemia (AML), include host factors in these mainly older patients, disease heterogeneity, lack of pathogenetic understanding, and a dearth of effective treatments. Even the issue of whether these clonal dis...
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Death from injury has increased by 20% over the last decade and accounts for more death than malaria, tubercolosis, and HIV combined. Hemorrhage requiring massive transfusion secondary to trauma and major surgery remains a major cause of potentially preventable deaths, and development of coagulopathy further substantiallyincreases the mortality rates of hemorrhaging patients. Classically, massi...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/345774b0